AustralieFrV1, Main, Exploration, bibRecord, 003382

Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis.

Identifieur interne : 003382 ( Main/Exploration ); précédent : 003381; suivant : 003383

Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis.

Auteurs : Marie Robin [France] ; Federica Giannotti [France] ; Eric Deconinck [France] ; Mohamad Mohty [France] ; Mauricette Michallet [France] ; Guillermo Sanz [Espagne] ; Patrice Chevallier [France] ; Jean-Yves Cahn [France] ; Faezeh Legrand [France] ; Montserrat Rovira [Espagne] ; Jakob Passweg [Suisse] ; Jorge Sierra [Espagne] ; Stephanie Nguyen [France] ; Natacha Maillard [France] ; Ibrahim Yakoub-Agha [France] ; Werner Linkesch [Autriche] ; Paul Cannell [Australie] ; Magda Marcatti [Italie] ; Jacques-Olivier Bay [France] ; Yves Chalandon [Suisse] ; Nicolaus Kröger [Allemagne] ; Eliane Gluckman [Monaco] ; Vanderson Rocha [Royaume-Uni] ; Eduardo Olavarria [Espagne] ; Annalisa Ruggeri [France]

Source :

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2014.

RBID : pubmed:24946719

Descripteurs français

English descriptors

KwdEn :
- Cord Blood Stem Cell Transplantation (adverse effects), Cord Blood Stem Cell Transplantation (methods), Female, Fetal Blood, Hematopoietic Stem Cell Transplantation (methods), Humans, Male, Middle Aged, Primary Myelofibrosis (therapy), Transplantation Conditioning (methods), Treatment Outcome, Unrelated Donors.
MESH :
- adverse effects : Cord Blood Stem Cell Transplantation.
- methods : Cord Blood Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation, Transplantation Conditioning.
- therapy : Primary Myelofibrosis.
- Female, Fetal Blood, Humans, Male, Middle Aged, Treatment Outcome, Unrelated Donors.

Abstract

To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. Seven patients had secondary acute myeloid leukemia (AML) at UCBT, and median age at UCBT was 54 years. Twenty-four patients received a reduced-intensity conditioning (RIC) regimen, and 17 of 35 patients received total body irradiation (2 to 12 Gy)-fludarabine-cyclophosphamide (TCF) conditioning. The median follow-up was 24 months. The cumulative incidence of neutrophil recovery at 60 days was 80%. Fifteen patients relapsed after UCBT. The 2-year overall survival and event-free-survival (EFS) rates were 44% and 30%, respectively. All patients given TCF achieved neutrophil and platelet recovery, and the use of TCF was associated with superior EFS in the RIC population (44% versus 0%, P = .001). Patients with transformation to AML had similar outcomes to patients with less advanced stages. In conclusion, despite graft failure remaining a major concern, the role of UCBT in the management of MF, especially using RIC TCF-based regimens, deserves further investigation to improve results.

DOI: 10.1016/j.bbmt.2014.06.011
PubMed: 24946719

Affiliations:

Le document en format XML

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<author><name sortKey="Sanz, Guillermo" sort="Sanz, Guillermo" uniqKey="Sanz G" first="Guillermo" last="Sanz">Guillermo Sanz</name>
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<author><name sortKey="Chevallier, Patrice" sort="Chevallier, Patrice" uniqKey="Chevallier P" first="Patrice" last="Chevallier">Patrice Chevallier</name>
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<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
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<author><name sortKey="Legrand, Faezeh" sort="Legrand, Faezeh" uniqKey="Legrand F" first="Faezeh" last="Legrand">Faezeh Legrand</name>
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<author><name sortKey="Rovira, Montserrat" sort="Rovira, Montserrat" uniqKey="Rovira M" first="Montserrat" last="Rovira">Montserrat Rovira</name>
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<author><name sortKey="Passweg, Jakob" sort="Passweg, Jakob" uniqKey="Passweg J" first="Jakob" last="Passweg">Jakob Passweg</name>
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<country xml:lang="fr">Suisse</country>
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<wicri:noRegion>Basel</wicri:noRegion>
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</author>
<author><name sortKey="Sierra, Jorge" sort="Sierra, Jorge" uniqKey="Sierra J" first="Jorge" last="Sierra">Jorge Sierra</name>
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</affiliation>
</author>
<author><name sortKey="Nguyen, Stephanie" sort="Nguyen, Stephanie" uniqKey="Nguyen S" first="Stephanie" last="Nguyen">Stephanie Nguyen</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maillard, Natacha" sort="Maillard, Natacha" uniqKey="Maillard N" first="Natacha" last="Maillard">Natacha Maillard</name>
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<placeName><region type="region">Nouvelle-Aquitaine</region>
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<author><name sortKey="Yakoub Agha, Ibrahim" sort="Yakoub Agha, Ibrahim" uniqKey="Yakoub Agha I" first="Ibrahim" last="Yakoub-Agha">Ibrahim Yakoub-Agha</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology, CHRU de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Linkesch, Werner" sort="Linkesch, Werner" uniqKey="Linkesch W" first="Werner" last="Linkesch">Werner Linkesch</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical University Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Medical University Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cannell, Paul" sort="Cannell, Paul" uniqKey="Cannell P" first="Paul" last="Cannell">Paul Cannell</name>
<affiliation wicri:level="1"><nlm:affiliation>Hematology, Royal Perth Hospital, Perth, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Hematology, Royal Perth Hospital, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
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<author><name sortKey="Marcatti, Magda" sort="Marcatti, Magda" uniqKey="Marcatti M" first="Magda" last="Marcatti">Magda Marcatti</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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</placeName>
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<author><name sortKey="Bay, Jacques Olivier" sort="Bay, Jacques Olivier" uniqKey="Bay J" first="Jacques-Olivier" last="Bay">Jacques-Olivier Bay</name>
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<wicri:regionArea>Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, Hotel-Dieu, Clermont-Ferrand</wicri:regionArea>
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<author><name sortKey="Chalandon, Yves" sort="Chalandon, Yves" uniqKey="Chalandon Y" first="Yves" last="Chalandon">Yves Chalandon</name>
<affiliation wicri:level="1"><nlm:affiliation>Hôpitaux universitaires de Genève, Suisse.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Hôpitaux universitaires de Genève</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroger, Nicolaus" sort="Kroger, Nicolaus" uniqKey="Kroger N" first="Nicolaus" last="Kröger">Nicolaus Kröger</name>
<affiliation wicri:level="3"><nlm:affiliation>University Medical Center Hamburg-Eppendorf Center of Oncology, Department of Stem Cell Transplantation, Chairman of the CMWP EBMT, Hamburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Medical Center Hamburg-Eppendorf Center of Oncology, Department of Stem Cell Transplantation, Chairman of the CMWP EBMT, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
<affiliation wicri:level="1"><nlm:affiliation>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Monacord, Centre scientifique de Monaco, Monaco.</nlm:affiliation>
<country xml:lang="fr">Monaco</country>
<wicri:regionArea>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Monacord, Centre scientifique de Monaco</wicri:regionArea>
<wicri:noRegion>Centre scientifique de Monaco</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name>
<affiliation wicri:level="3"><nlm:affiliation>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Department of Clinical Haematology, Bone Marrow Transplant Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Department of Clinical Haematology, Bone Marrow Transplant Unit, Oxford University Hospitals NHS Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de Navarra, Chairman of MPN Subcommittee of the CMWP-EBMT, Pamplona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de Navarra, Chairman of MPN Subcommittee of the CMWP-EBMT, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name>
<affiliation wicri:level="3"><nlm:affiliation>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Hematologie, CHU Saint-Antoine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Hematologie, CHU Saint-Antoine, Paris</wicri:regionArea>
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<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis.</title>
<author><name sortKey="Robin, Marie" sort="Robin, Marie" uniqKey="Robin M" first="Marie" last="Robin">Marie Robin</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology-Bone Marrow Transplantation, Saint-Louis Hospital, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
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</author>
<author><name sortKey="Giannotti, Federica" sort="Giannotti, Federica" uniqKey="Giannotti F" first="Federica" last="Giannotti">Federica Giannotti</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Eurocord International Registry, Hôpital Saint-Louis, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Deconinck, Eric" sort="Deconinck, Eric" uniqKey="Deconinck E" first="Eric" last="Deconinck">Eric Deconinck</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Hématologie, CHU de Besançon, INSERM U-645, Université de Franche-Comté, Besançon</wicri:regionArea>
<placeName><region type="region">Bourgogne-Franche-Comté</region>
<region type="old region">Franche-Comté</region>
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<settlement type="city" wicri:auto="siege">Besançon</settlement>
</placeName>
<orgName type="university">Université de Franche-Comté</orgName>
</affiliation>
</author>
<author><name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematologie, CHU Saint-Antoine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematologie, CHU Saint-Antoine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Michallet, Mauricette" sort="Michallet, Mauricette" uniqKey="Michallet M" first="Mauricette" last="Michallet">Mauricette Michallet</name>
<affiliation wicri:level="1"><nlm:affiliation>Hematology Department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology Department 1G, Centre Hospitalier Lyon Sud, Pierre Benite</wicri:regionArea>
<wicri:noRegion>Pierre Benite</wicri:noRegion>
<wicri:noRegion>Pierre Benite</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanz, Guillermo" sort="Sanz, Guillermo" uniqKey="Sanz G" first="Guillermo" last="Sanz">Guillermo Sanz</name>
<affiliation wicri:level="1"><nlm:affiliation>Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chevallier, Patrice" sort="Chevallier, Patrice" uniqKey="Chevallier P" first="Patrice" last="Chevallier">Patrice Chevallier</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology, Nantes University Hospital, Nantes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology, Nantes University Hospital, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Legrand, Faezeh" sort="Legrand, Faezeh" uniqKey="Legrand F" first="Faezeh" last="Legrand">Faezeh Legrand</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology, Nice University Hospital, Nice, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology, Nice University Hospital, Nice</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Nice</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rovira, Montserrat" sort="Rovira, Montserrat" uniqKey="Rovira M" first="Montserrat" last="Rovira">Montserrat Rovira</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology, Hospital Clínic, IDIBAPS, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hematology, Hospital Clínic, IDIBAPS, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Passweg, Jakob" sort="Passweg, Jakob" uniqKey="Passweg J" first="Jakob" last="Passweg">Jakob Passweg</name>
<affiliation wicri:level="1"><nlm:affiliation>Hematology Department, Basel University Hospital, Basel, Switzerland.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Hematology Department, Basel University Hospital, Basel</wicri:regionArea>
<wicri:noRegion>Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sierra, Jorge" sort="Sierra, Jorge" uniqKey="Sierra J" first="Jorge" last="Sierra">Jorge Sierra</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Hematology, Hospital De Sant Pau, Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Clinical Hematology, Hospital De Sant Pau, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nguyen, Stephanie" sort="Nguyen, Stephanie" uniqKey="Nguyen S" first="Stephanie" last="Nguyen">Stephanie Nguyen</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology, Hôpital Pitié-Salpêtrière, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maillard, Natacha" sort="Maillard, Natacha" uniqKey="Maillard N" first="Natacha" last="Maillard">Natacha Maillard</name>
<affiliation wicri:level="3"><nlm:affiliation>CHU Hematology, Poitiers, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CHU Hematology, Poitiers</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Poitou-Charentes</region>
<settlement type="city">Poitiers</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yakoub Agha, Ibrahim" sort="Yakoub Agha, Ibrahim" uniqKey="Yakoub Agha I" first="Ibrahim" last="Yakoub-Agha">Ibrahim Yakoub-Agha</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology, CHRU de Lille, Lille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hematology, CHRU de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Linkesch, Werner" sort="Linkesch, Werner" uniqKey="Linkesch W" first="Werner" last="Linkesch">Werner Linkesch</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical University Graz, Graz, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Medical University Graz, Graz</wicri:regionArea>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cannell, Paul" sort="Cannell, Paul" uniqKey="Cannell P" first="Paul" last="Cannell">Paul Cannell</name>
<affiliation wicri:level="1"><nlm:affiliation>Hematology, Royal Perth Hospital, Perth, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Hematology, Royal Perth Hospital, Perth</wicri:regionArea>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marcatti, Magda" sort="Marcatti, Magda" uniqKey="Marcatti M" first="Magda" last="Marcatti">Magda Marcatti</name>
<affiliation wicri:level="3"><nlm:affiliation>Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bay, Jacques Olivier" sort="Bay, Jacques Olivier" uniqKey="Bay J" first="Jacques-Olivier" last="Bay">Jacques-Olivier Bay</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, Hotel-Dieu, Clermont-Ferrand, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Thérapie Cellulaire et d'Hématologie Clinique Adulte, Hotel-Dieu, Clermont-Ferrand</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
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</author>
<author><name sortKey="Chalandon, Yves" sort="Chalandon, Yves" uniqKey="Chalandon Y" first="Yves" last="Chalandon">Yves Chalandon</name>
<affiliation wicri:level="1"><nlm:affiliation>Hôpitaux universitaires de Genève, Suisse.</nlm:affiliation>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Hôpitaux universitaires de Genève</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroger, Nicolaus" sort="Kroger, Nicolaus" uniqKey="Kroger N" first="Nicolaus" last="Kröger">Nicolaus Kröger</name>
<affiliation wicri:level="3"><nlm:affiliation>University Medical Center Hamburg-Eppendorf Center of Oncology, Department of Stem Cell Transplantation, Chairman of the CMWP EBMT, Hamburg, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Medical Center Hamburg-Eppendorf Center of Oncology, Department of Stem Cell Transplantation, Chairman of the CMWP EBMT, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
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</affiliation>
</author>
<author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
<affiliation wicri:level="1"><nlm:affiliation>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Monacord, Centre scientifique de Monaco, Monaco.</nlm:affiliation>
<country xml:lang="fr">Monaco</country>
<wicri:regionArea>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Monacord, Centre scientifique de Monaco</wicri:regionArea>
<wicri:noRegion>Centre scientifique de Monaco</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name>
<affiliation wicri:level="3"><nlm:affiliation>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Department of Clinical Haematology, Bone Marrow Transplant Unit, Oxford University Hospitals NHS Trust, Oxford, United Kingdom.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Department of Clinical Haematology, Bone Marrow Transplant Unit, Oxford University Hospitals NHS Trust, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olavarria, Eduardo" sort="Olavarria, Eduardo" uniqKey="Olavarria E" first="Eduardo" last="Olavarria">Eduardo Olavarria</name>
<affiliation wicri:level="1"><nlm:affiliation>Hospital de Navarra, Chairman of MPN Subcommittee of the CMWP-EBMT, Pamplona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospital de Navarra, Chairman of MPN Subcommittee of the CMWP-EBMT, Pamplona</wicri:regionArea>
<wicri:noRegion>Pamplona</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name>
<affiliation wicri:level="3"><nlm:affiliation>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Hematologie, CHU Saint-Antoine, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Eurocord International Registry, Hôpital Saint-Louis, Paris, France; Hematologie, CHU Saint-Antoine, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cord Blood Stem Cell Transplantation (adverse effects)</term>
<term>Cord Blood Stem Cell Transplantation (methods)</term>
<term>Female</term>
<term>Fetal Blood</term>
<term>Hematopoietic Stem Cell Transplantation (methods)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Primary Myelofibrosis (therapy)</term>
<term>Transplantation Conditioning (methods)</term>
<term>Treatment Outcome</term>
<term>Unrelated Donors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Conditionnement pour greffe ()</term>
<term>Donneurs non apparentés</term>
<term>Femelle</term>
<term>Humains</term>
<term>Myélofibrose primitive ()</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sang foetal</term>
<term>Transplantation de cellules souches de sang du cordon ()</term>
<term>Transplantation de cellules souches de sang du cordon (effets indésirables)</term>
<term>Transplantation de cellules souches hématopoïétiques ()</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Cord Blood Stem Cell Transplantation</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Transplantation de cellules souches de sang du cordon</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cord Blood Stem Cell Transplantation</term>
<term>Hematopoietic Stem Cell Transplantation</term>
<term>Transplantation Conditioning</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Primary Myelofibrosis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Fetal Blood</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
<term>Unrelated Donors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Conditionnement pour greffe</term>
<term>Donneurs non apparentés</term>
<term>Femelle</term>
<term>Humains</term>
<term>Myélofibrose primitive</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Sang foetal</term>
<term>Transplantation de cellules souches de sang du cordon</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. Seven patients had secondary acute myeloid leukemia (AML) at UCBT, and median age at UCBT was 54 years. Twenty-four patients received a reduced-intensity conditioning (RIC) regimen, and 17 of 35 patients received total body irradiation (2 to 12 Gy)-fludarabine-cyclophosphamide (TCF) conditioning. The median follow-up was 24 months. The cumulative incidence of neutrophil recovery at 60 days was 80%. Fifteen patients relapsed after UCBT. The 2-year overall survival and event-free-survival (EFS) rates were 44% and 30%, respectively. All patients given TCF achieved neutrophil and platelet recovery, and the use of TCF was associated with superior EFS in the RIC population (44% versus 0%, P = .001). Patients with transformation to AML had similar outcomes to patients with less advanced stages. In conclusion, despite graft failure remaining a major concern, the role of UCBT in the management of MF, especially using RIC TCF-based regimens, deserves further investigation to improve results.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Monaco</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
</country>
<region><li>Angleterre</li>
<li>Auvergne (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bourgogne-Franche-Comté</li>
<li>Catalogne</li>
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<li>Hambourg</li>
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<li>Lombardie</li>
<li>Nord-Pas-de-Calais</li>
<li>Nouvelle-Aquitaine</li>
<li>Oxfordshire</li>
<li>Pays de la Loire</li>
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<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhône-Alpes</li>
<li>Île-de-France</li>
</region>
<settlement><li>Barcelone</li>
<li>Besançon</li>
<li>Clermont-Ferrand</li>
<li>Grenoble</li>
<li>Hambourg</li>
<li>Lille</li>
<li>Milan</li>
<li>Nantes</li>
<li>Nice</li>
<li>Oxford</li>
<li>Paris</li>
<li>Poitiers</li>
</settlement>
<orgName><li>Université de Franche-Comté</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Robin, Marie" sort="Robin, Marie" uniqKey="Robin M" first="Marie" last="Robin">Marie Robin</name>
</region>
<name sortKey="Bay, Jacques Olivier" sort="Bay, Jacques Olivier" uniqKey="Bay J" first="Jacques-Olivier" last="Bay">Jacques-Olivier Bay</name>
<name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
<name sortKey="Chevallier, Patrice" sort="Chevallier, Patrice" uniqKey="Chevallier P" first="Patrice" last="Chevallier">Patrice Chevallier</name>
<name sortKey="Deconinck, Eric" sort="Deconinck, Eric" uniqKey="Deconinck E" first="Eric" last="Deconinck">Eric Deconinck</name>
<name sortKey="Giannotti, Federica" sort="Giannotti, Federica" uniqKey="Giannotti F" first="Federica" last="Giannotti">Federica Giannotti</name>
<name sortKey="Legrand, Faezeh" sort="Legrand, Faezeh" uniqKey="Legrand F" first="Faezeh" last="Legrand">Faezeh Legrand</name>
<name sortKey="Maillard, Natacha" sort="Maillard, Natacha" uniqKey="Maillard N" first="Natacha" last="Maillard">Natacha Maillard</name>
<name sortKey="Michallet, Mauricette" sort="Michallet, Mauricette" uniqKey="Michallet M" first="Mauricette" last="Michallet">Mauricette Michallet</name>
<name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<name sortKey="Nguyen, Stephanie" sort="Nguyen, Stephanie" uniqKey="Nguyen S" first="Stephanie" last="Nguyen">Stephanie Nguyen</name>
<name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name>
<name sortKey="Yakoub Agha, Ibrahim" sort="Yakoub Agha, Ibrahim" uniqKey="Yakoub Agha I" first="Ibrahim" last="Yakoub-Agha">Ibrahim Yakoub-Agha</name>
</country>
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<name sortKey="Chalandon, Yves" sort="Chalandon, Yves" uniqKey="Chalandon Y" first="Yves" last="Chalandon">Yves Chalandon</name>
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<country name="Autriche"><noRegion><name sortKey="Linkesch, Werner" sort="Linkesch, Werner" uniqKey="Linkesch W" first="Werner" last="Linkesch">Werner Linkesch</name>
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<country name="Australie"><noRegion><name sortKey="Cannell, Paul" sort="Cannell, Paul" uniqKey="Cannell P" first="Paul" last="Cannell">Paul Cannell</name>
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<country name="Italie"><region name="Lombardie"><name sortKey="Marcatti, Magda" sort="Marcatti, Magda" uniqKey="Marcatti M" first="Magda" last="Marcatti">Magda Marcatti</name>
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<country name="Allemagne"><region name="Hambourg"><name sortKey="Kroger, Nicolaus" sort="Kroger, Nicolaus" uniqKey="Kroger N" first="Nicolaus" last="Kröger">Nicolaus Kröger</name>
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<country name="Monaco"><noRegion><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name>
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<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis.

Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis.

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	Serveur d'exploration sur les relations entre la France et l'Australie
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